Cytokines and epilepsy
نویسندگان
چکیده
منابع مشابه
Cytokines and epilepsy
Epilepsy is a common chronic neurological disorder affecting approximately 8 out of 1000 people. Its pathophysiology, however, has remained elusive in many regards. Consequently, adequate seizure control is still lacking in about one third of patients. Cytokines are soluble mediators of cell communication that are critical in immune regulation. In recent years, studies have shown that epileptic...
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Statistical analysis of my data is not possible, but I have hints that the hemispheric differences of regulation [1] are due to dominant/non-dominant – and not to left/right hemisphere. I have no hints that they refl ect a dominant hemisphere’s requirement of a special immunological protection, but I am sure, that the immune and endocrine system is regulated by the CNS in an antagonistic but ma...
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In recent years, the functional disturbances of the immune system, both humoral and cell-mediated immunity, have been detected more often among persons with epilepsy than in general population. A number of irregularities in cytokine production have been found in epileptic patients. It shows that epileptic seizures stimulate, per se, synthesis of pro-inflammatory and pro-convulsive cytokines. So...
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Recent findings in experimental models and in the clinical setting highlight the possibility that inflammatory processes in the brain contribute to the etiopathogenesis of seizures and to the establishment of a chronic epileptic focus. Prototypical inflammatory cytokines such as IL-1 beta, TNF-alpha and IL-6 have been shown to be overexpressed in experimental models of seizures in brain areas o...
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Epilepsy is accompanied with a strong change in neuronal activity not only in excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmission, but also in neuromodulatory agents. Dopaminergic system, as an important neuromodulatory system of the brain, has significant effect on neuronal excitability. In addition, this system undergoes many changes in epileptic brain. Understanding the e...
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ژورنال
عنوان ژورنال: Seizure
سال: 2011
ISSN: 1059-1311
DOI: 10.1016/j.seizure.2010.12.005